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STAT – New York biotech debuts, targeting dormant metastatic cancer cells

A biotech based on the frightening fact that some cancer cells spread throughout the body even before a tumor is detectable emerged from stealth mode on Thursday, announcing it had raised roughly $60 million from, among others, early-stage venture capital companies and one of biotech’s 800-pound gorillas. Read full story by Sharon Begley here.

FierceBiotech – Biotech HiberCell launches with $60M+ to combat cancer relapse and metastasis

HiberCell, a new startup focused on preventing cancer metastasis and relapse, launched Thursday with research out of Mount Sinai and $60.75 million from the likes of ARCH Venture Partners, Hillhouse Capital and 6 Dimensions Capital. Read full story by Amirah Al Idrus here.

Endpoints – Arch joins Celgene, China investors bankrolling a pioneering New York biotech startup focused on a new approach to metastasis

Julio Aguirre-Ghiso has steered the work in his lab at Mount Sinai down some of the less-traveled pathways of cancer research. And it’s led him to launch a biotech — which is having its coming-out party today in New York — that has now set out to develop new medicines tailored for the field he’s … Continued

HiberCell Launches to Prevent Cancer Relapse and Metastasis with Novel Therapeutics

$60.75M funding round led by ARCH Venture Partners with 6 Dimensions Capital HiberCell will build on pioneering tumor dormancy research conducted by the Julio Aguirre-Ghiso Lab at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai NEW YORK–February 7, 2019 – /PR Newswire/–HiberCell, a biotechnology company developing therapeutics focused on preventing cancer … Continued

NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients

NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients Borgen E, Rypdal MC, Sosa MS, Renolen A, Schlichting E, Lønning PE, Synnestvedt M, Aguirre-Ghiso JA, Naume B. Breast Cancer Res. 2018 Oct 16;20(1):120. doi: 10.1186/s13058-018-1049-0. PMID: 30322396 [PubMed – in process] Free PMC Article

How dormant cancer persists and reawakens

How dormant cancer persists and reawakens Aguirre-Ghiso JA. Science. 2018 Sep 28;361(6409):1314-1315. doi: 10.1126/science.aav0191. No abstract available. PMID: 30262486 [PubMed – indexed for MEDLINE]

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

Mechanism of early dissemination and metastasis in Her2+ mammary cancer Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA.Nature. 2016 Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] Erratum in: Nature. 2017 Dec 13. PMID: 27974798 … Continued

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes Sosa MS, Parikh F, Maia AG, Estrada Y, Bosch A, Bragado P, Ekpin E, George A, Zheng Y, Lam HM, Morrissey C, Chung CY, Farias EF, Bernstein E, Aguirre-Ghiso JA. Nat Commun. 2015 Jan 30;6:6170. doi: 10.1038/ncomms7170.PMID: 25636082 [PubMed – indexed for MEDLINE] Free … Continued

Mechanisms of disseminated cancer cell dormancy: an awakening field

Mechanisms of disseminated cancer cell dormancy: an awakening field Sosa MS, Bragado P, Aguirre-Ghiso JA. Nat Rev Cancer. 2014 Sep;14(9):611-22. doi: 10.1038/nrc3793. Epub 2014 Aug 14. Review. PMID: 25118602 [PubMed – indexed for MEDLINE] Free PMC Article

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling Bragado P, Estrada Y, Parikh F, Krause S, Capobianco C, Farina HG, Schewe DM, Aguirre-Ghiso JA. Nat Cell Biol. 2013 Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27. PMID: 24161934 [PubMed – indexed for MEDLINE] Free PMC Article