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04.14.20 - Adaptive Stress Modulators

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

Authors: Eslam Mohamed, Rosa A. Sierra Jimena Trillo-Tinoco, Yu Cao Patrick Innamarato, Kyle K. Payne Alvaro de Mingo Pulido, Jessica Mandula Shuzhong Zhang, Paul Thevenot Subir Biswas, Sarah K. Abdalla, Tara Lee Costich Kay Hänggi, Carmen M. Anadon, Elsa R. Flores, Eric B. Haura, Shikhar Mehrotra, Shari Pilon-Thomas, Brian Ruffell, David H. Munn, Juan R. Cubillos-Ruiz, Jose R. Conejo-Garcia, Paulo C. Rodriguez

Article Immunity

04.01.20 - Microenvironment Modulator

A novel, phase 2 study in second line +, metastatic triple negative breast cancer patients shows promising clinical benefit for the combination of the immune checkpoint inhibitor, pembrolizumab (pembro), with the novel innate immune activator, Imprime PGG

Presented at the 2020 AACR Virtual Annual Meeting. Authors: O’Day SJ, Borges, VF, Chmielowski B, et al.

Article ASCO Post

03.13.20 - Adaptive Stress Modulators

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

Authors: Sylwia Bartoszewska & James F. Collawn

Article Cellular & Molecular Biology Letters

03.04.20 - Microenvironment Modulator

Defining trained immunity and its role in health and disease

Authors: Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier & Eicke Latz

Article Nature Reviews Immunology

12.01.19 - Microenvironment Modulator

Response and clinical benefit assessment of the combination of the dectin-1 agonist Imprime PGG and anti-PD-1 pembrolizumab in chemotherapy-resistant metastatic triple negative breast cancer (TNBC)

Presented at San Antonio Breast Cancer Conference. Authors: Uhlik M., Bose N., Cox J., Mattson P., Gargano M., O'Day S., Borges V., Chmielowski B., Rao R., Abu-Khalaf M., Stopeck A., Chisamore M., Osterwalder B., Graff J.

Poster

11.01.19 - Microenvironment Modulator

Association of immunopharmacodynamic responses of Imprime PGG plus pembrolizumab with clinical benefit in metastatic triple negative breast cancer (TNBC) subjects failing front-line chemotherapy

Presented at 2019 SITC Annual Conference. Authors: Nadine R. Ottoson, Anissa SH Chan, Xiaohong Qiu, Ben Harrison, Richard Walsh, Paulette Mattson, Michele Gargano, Joanna Cox, Michael Chisamore, Mark Uhlik, Jeremy R. Graff, and Nandita Bose

Poster

11.01.19 - Microenvironment Modulator

Clinical benefit evident with early immunopharmacodynamic responses in prior checkpoint failed metastatic melanoma patients treated with Imprime PGG and pembrolizumab

Presented at 2019 SITC Annual Conference. Authors: Anissa SH Chan, Nadine R. Ottoson, XiaohongQiu, Ben Harrison, Richard Walsh, Paulette Mattson, Michele Gargano, Joanna Cox, Michael Chisamore, Mark Uhlik, Jeremy R. Graff, and Nandita Bose. 

Poster

10.01.19 - Dormancy & Metastasis

Tumor Dormancy and Slow-Cycling Cancer Cells

Authors: John E. Davis Jr., Jason Kirk, Yibing Ji, Dean G. Tang

Article Advances in Experimental Medicine and Biology

09.01.19 - Dormancy & Metastasis

Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

Authors: Elena Butturini, Alessandra Carcereri de Prati, Diana Boriero, Sofia Mariotto

Article International Journal of Molecular Sciences

05.01.19 - Microenvironment Modulator

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Authors: Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea

Article Cell Reports

05.01.19 - Microenvironment Modulator

Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers

Authors: Nandita Bose, Nadine R. Ottoson, Xiaohong Qiu, Ben Harrison, Jamie R. Lowe, Mark T. Uhlik, Blaine T. Rathmann, Takashi O. Kangas, Lindsay R. Jordan, Kathleen E. Ertelt, Adria Bykowski Jonas, Richard M. Walsh, Anissa S. H. Chan, Ross B. Fulton, Steven M. Leonardo, Kathryn A. Fraser, Keith B. Gorden, Mark A. Matson, Jeremy R. Graff and Richard D. Huhn

Article The Journal of Immunology

05.01.19 - Adaptive Stress Modulators

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells

Authors: Sheng-Kai Hsu, Chien-Chih Chiu, Hans-Uwe Dahms, Chon-Kit Chou, Chih-Mei Cheng, Wen-Tsan Chang, Kai-Chun Cheng, Hui-Min David Wang, I-Ling Lin

Article International Journal of Molecular Sciences

04.01.19 - Microenvironment Modulator

Therapeutic targeting of trained immunity

Authors: Willem J. M. Mulder, Jordi Ochando, Leo A. B. Joosten, Zahi A. Fayad & Mihai G. Netea

Article Nature Reviews Drug Discovery

03.01.19 - Adaptive Stress Modulators

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

Authors: Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia & Paulo C. Rodriguez

Article Nature Communications

02.01.19 - Dormancy & Metastasis

Dormancy in cancer

Authors: Hiroko Endo, Masahiro Inoue

Article Cancer Science

01.01.19 - Dormancy & Metastasis

Dormancy and cancer stem cells: An enigma for cancer therapeutic targeting

Authors: Sarmistha Talukdar, Praveen Bhoopathi, Luni Emdad, Swadesh Das, Devanand Sarkar, Paul B Fisher

Article Advacnced Cancer Research

01.01.19 - Dormancy & Metastasis

Targeting Cancer Cell Dormancy

Authors: Ariadna Recasens, Lenka Munoz

Article Trends in Pharmacology Science

10.01.18 - Dormancy & Metastasis

NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients

Authors: Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso & Bjørn Naume

Article Breast Cancer Research

09.01.18 - Dormancy & Metastasis

How dormant cancer persists and reawakens

Author: Julio A Aguirre-Ghiso

Article Science

06.01.18 - Adaptive Stress Modulators

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

Authors: Arnaud Pommier, Naishitha Anaparthy, Nicoletta Memos, Z. Larkin Kelley, Alizée Gouronnec, Ran Yan, VCédric Auffray, Jean Albrengues, Mikala Egeblad, Christine A. Iacobuzio-Donahue, Scott K. Lyons, Douglas T. Fearon

Article Science

05.01.18 - Adaptive Stress Modulators

Development of a stress response therapy targeting aggressive prostate cancer

Authors: Hao G Nguyen , Crystal S Conn, Yae Kye, Lingru Xue, Craig M Forester, Janet E Cowan, Andrew C Hsieh, John T Cunningham, Charles Truillet, Feven Tameire, Michael J Evans, Christopher P Evans, Joy C Yang, Byron Hann, Constantinos Koumenis, Peter Walter, Peter R Carroll, Davide Ruggero

Article Science Translational Medicine

04.01.18 - Microenvironment Modulator

Imprime (β-1,3/1,6 glucan) synergizes with a CD40 agonist to stimulate T cell-dependent antitumor activity in a poorly immunogenic model of pancreatic carcinoma

American Association for Cancer Research Annual Meeting. Authors: Mingen Liu, Kathleen Graham, Anissa SH. Chan, Nadine R. Ottoson, Nandita Bose, Gregory L. Beatty

Poster

04.01.18 - Microenvironment Modulator

Imprime PGG synergizes with anti-angiogenic antibodies to repolarize the immune microenvironment, suppressing xenograft tumor growth in vivo

American Association for Cancer Research Annual Meeting. Authors: Kathryn Fraser, Nadine Ottoson, Xiahong Qiu, Anissa SH Chan, Adria Jonas, Takashi Kangas, Jeremy Graff, Nandita Bose

Poster

04.01.18 - Microenvironment Modulator

Imprime PGG, a soluble yest β-glucan PAMP, enhancement of anit-tumor responses in comination with tumor targeting antibody is highly dependent on NK cell killing

American Association for Cancer Research Annual Meeting. Authors: Kathryn A. Fraser, Takashi Kangas, Ross B. Fulton, Steven M. Leonardo, Ben Harrison, Yumi Yokoyama, Nandita Bose, Jeremy R. Graff, Mark Uhlik, and Keith B. Gorden

Poster

03.01.18 - Adaptive Stress Modulators

The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma

Authors: Peter Makhov, Sei Naito, Miki Haifler, Alexander Kutikov, Yanis Boumber, Robert G. Uzzo & Vladimir M. Kolenko

Article Cell Death & Disease

02.01.18 - Microenvironment Modulator

A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of advanced non-small cell lung cancer

Authors: Walburga Engel-Riedel 1, Jamie Lowe 2, Paulette Mattson 2, J Richard Trout 3, Richard D Huhn 2, Michele Gargano 2, Myra L Patchen 4 5, Richard Walsh 2, My My Trinh 6, Mariève Dupuis 6, Folker Schneller 7

Article Journal for ImmunoTherapy of Cancer

01.01.18 - Dormancy & Metastasis

Role of HIF-1 in Cancer Progression: Novel Insights. A Review

Authors: Aldo Pezzuto, Elisabetta Carico

Article Current Molecular Medicine

01.01.18 - Microenvironment Modulator

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Authors: Ioannis Mitroulis, Klara Ruppova, Baomei Wang, Lan-Sun Chen, Michal Grzybek, Tatyana Grinenko, Anne Eugster, Maria Troullinaki, Alessandra Palladini, Ioannis Kourtzelis, Antonios Chatzigeorgiou, Andreas Schlitzer, Marc Beyer, Leo A.B. Joosten, Berend Isermann, Mathias Lesche, Andreas Petzold, Kai Simons, Ian Henry, Andreas Dahl, Joachim L. Schultze, Ben Wielockx, Nicola Zamboni, Peter Mirtschink, Ünal Coskun, George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis

Article Cell

10.01.17 - Adaptive Stress Modulators

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L

Authors: Yu-Xiong Feng, Dexter X. Jin, Ethan S. Sokol, Ferenc Reinhardt, Daniel H. Miller & Piyush B. Gupta

Article Nature Communications

01.01.17 - Dormancy & Metastasis

Circulating and disseminated tumor cells: harbingers or initiators of metastasis?

Authors: Arko Dasgupta Andrea R. Lim Cyrus M. Ghajar

Article Molecular Oncology

12.01.16 - Dormancy & Metastasis

Mechanism of early dissemination and metastasis in Her2 + mammary cancer

Authors: Kathryn L. Harper, Maria Soledad Sosa, David Entenberg, Hedayatollah Hosseini, Julie F. Cheung, Rita Nobre, Alvaro Avivar-Valderas, Chandandaneep Nagi, Nomeda Girnius, Roger J. Davis, Eduardo F. Farias, John Condeelis, Christoph A. Klein & Julio A. Aguirre-Ghiso

Article Nature

11.01.16 - Microenvironment Modulator

Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Authors: Anissa S. H. Chan ,Adria Bykowski Jonas ,Xiaohong Qiu,Nadine R. Ottoson,Richard M. Walsh,Keith B Gorden,Ben Harrison,Peter J. Maimonis,Steven M. Leonardo,Kathleen E. Ertelt,Michael E. Danielson,Kyle S. Michel,Mariana Nelson,Jeremy R. Graff,Myra L. Patchen,Nandita Bose

Article PLOS One

01.01.16 - Adaptive Stress Modulators

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

Authors: W Rozpedek, D Pytel, B Mucha, H Leszczynska, J A Diehl, I Majsterek

Article Current Molecular Medicine

08.01.15 - Adaptive Stress Modulators

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

Authors: Feven Tameire, Ioannis I Verginadis, Constantinos Koumenis

Article Seminars in Cancer Biology

01.01.15 - Dormancy & Metastasis

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

Authors: Maria Soledad Sosa, Falguni Parikh, Alexandre Gaspar Maia, Yeriel Estrada, Almudena Bosch, Paloma Bragado, Esther Ekpin, Ajish George, Yang Zheng, Hung-Ming Lam, Colm Morrissey, Chi-Yeh Chung, Eduardo F. Farias, Emily Bernstein & Julio A. Aguirre-Ghiso

Article Nature Communications

08.01.14 - Dormancy & Metastasis

Mechanisms of disseminated cancer cell dormancy: an awakening field

Authors: María Soledad Sosa, Paloma Bragado & Julio A. Aguirre-Ghiso

Article Nature Reviews Cancer

04.01.14 - Microenvironment Modulator

Differential regulation of oxidative burst by distinct beta-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells

Authors: Nandita Bose 1, Lindsay R Wurst, Anissa S H Chan, Christine M Dudney, Megan L LeRoux, Michael E Danielson, Paul M Will, Sonja E Nodland, Myra L Patchen, Jurandir J Dalle Lucca, Frank J Lebeda, John P Vasilakos

Article Glycobiology

11.01.13 - Dormancy & Metastasis

Mechanisms governing metastatic dormancy and reactivation

Author: Filippo G Giancotti

Article Cell

10.01.13 - Dormancy & Metastasis

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

Authors: Paloma Bragado, Yeriel Estrada, Falguni Parikh, Sarah Krause, Carla Capobianco, Hernan G. Farina, Denis M. Schewe & Julio A. Aguirre-Ghiso

Article Nature Cell Biology

08.01.13 - Microenvironment Modulator

Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement-dependent

Authors: Nandita Bose, Anissa S. H. Chan, Faimola Guerrero, Carolyn M. Maristany, Xiaohong Qiu, Richard M. Walsh, Kathleen E. Ertelt, Adria Bykowski Jonas, Keith B. Gorden, Christine M. Dudney, Lindsay R. Wurst, Michael E. Danielson, Natalie Elmasry, Andrew S. Magee, Myra L. Patchen and John P. Vasilakos

Article Frontiers in Immunology

03.01.13 - Adaptive Stress Modulators

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

Authors: Kasper M. Rouschop, Ludwig J. Dubois, Tom G. Keulers, Twan van den Beucken, Philippe Lambin, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, and Bradly G. Wouters

Article PNAS

11.01.12 - Adaptive Stress Modulators

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

Authors: Lori S. Hart, John T. Cunningham, Tatini Datta, Souvik Dey, Feven Tameire, Stacey L. Lehman, Bo Qiu,1 Haiyan Zhang, George Cerniglia, Meixia Bi, Yan Li, Yan Gao, Huayi Liu, Changhong Li, Amit Maity, Andrei Thomas-Tikhonenko, Alexander E. Perl, Albert Koong, Serge Y. Fuchs, J. Alan Diehl, Ian G. Mills, Davide Ruggero, and Constantinos Koumenis

Article Journal of Clinical Investigation

05.01.12 - Adaptive Stress Modulators

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

Authors: E Bobrovnikova-Marjon, C Grigoriadou, D Pytel, F Zhang, J Ye, C Koumenis, D Cavener & J A Diehl

Article Oncogene

06.01.11 - Microenvironment Modulator

Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans

Authors: Chunjian Qi, Yihua Cai, Lacey Gunn, Chuanlin Ding, Bing Li, Goetz Kloecker, Keqing Qian, John Vasilakos, Shinobu Saijo, Yoichiro Iwakura, John R Yannelli, Jun Yan

Article Blood

04.01.11 - Microenvironment Modulator

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

Authors: Helen S. Goodridge, Christopher N. Reyes, Courtney A. Becker, Tamiko R. Katsumoto, Jun Ma, Andrea J. Wolf, Nandita Bose, Anissa S. H. Chan, Andrew S. Magee, Michael E. Danielson, Arthur Weiss, John P. Vasilakos & David M. Underhill

Article Nature

02.01.08 - Microenvironment Modulator

Yeast-Derived β-Glucan Augments the Therapeutic Efficacy Mediated by Anti–Vascular Endothelial Growth Factor Monoclonal Antibody in Human Carcinoma Xenograft Models

Authors: Carolina Salvador, Bing Li, Richard Hansen, Daniel E. Cramer, Maiying Kong and Jun Yan

Article Clinical Cancer Research

08.01.07 - Microenvironment Modulator

Combined yeast β-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil chemotaxis via regulation of decay-accelerating factor CD55

Authors: Bing Li, Daniel J. Allendorf, Richard Hansen, Jose Marroquin, Daniel E. Cramer, Claire L. Harris and Jun Yan

Article Clinical Cancer Research

08.01.06 - Microenvironment Modulator

Yeast β-Glucan Amplifies Phagocyte Killing of iC3b-Opsonized Tumor Cells via Complement Receptor 3-Syk-Phosphatidylinositol 3-Kinase Pathway

Authors: Bing Li, Daniel J. Allendorf, Richard Hansen, Jose Marroquin, Chuanlin Ding, Daniel E. Cramer and Jun Yan

Article The Journal of Immunology

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